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Image de tissu in vitro observée au microscope à fluorescence Image de tissu in vitro observée au micrscope à fluorescence et par impédancemétrie Image d'un tissu in vivo par OCT Image d'une plateforme de test optique et électrique pour tissu in vitro Image d'un stomate obtenur à l'aide de la plateforme de test Image de tracking de particule à la surface d'un tissu d'épithélium pulmonaire in vitro Image d'une partie de plaque de test avec membrane poreuse et réseau d'électrode produite par tampographie Image reconstruite d'une série d'image IRM d'un cerveau humain et application de méthode de traitement d'images Image d'un réseau d'électrode avec tissu in vitro observée en fluorescence Image d'un microarray de protéine basé sur la dépose de de 24 microgouttes en parallèle Image d'une bouture de pommier avec hormone de croissance marquée au carbone 14

Qui sommes-nous?

Prof. Dr. Philippe Passeraub

 

Dr ès sciences techniques EPF, Ing. dipl. EPF microtechnique

Professeur HES
Répondant pour la recherche dans l'axe micro- et bio-ingénierie

Campus Biotech, B3.04
Tél.: +41 (0)22 54 62 632 /-3
Courriel: Philippe.Passeraub (at) hesge.ch

Microtechniques, Transducteurs Microtechniques, Microfluidique, Capteurs et Instrumentation en Bio-Ingénierie.
Institut des Sciences et des Technologies Industrielles, Master Research Unit Technologies Industrielles

Publications

Patents

  1. MEDICAL DEVICE, KIT AND METHOD FOR SENSING A THUMB COMPRESSION FORCE (EP16200651.4) (2016).
  2. Method for the perfusion of brain tissue slices (Provisional patent, report of invention JHU 4156).
  3. Microstructure comprising an integrated circuit in a substrate whose surface is provided with a planar coil (EP0969512, US6194961, CN1242605, JP2000031384)
  4. Timepiece having an inductive or capacitive sensor for detecting at least one angular position of gear-wheel within the timepiece (EP0952426, JP11326555)

Book and book chapter

  1. P. A. Passeraub and N. V. Thakor, "Interfacing Neural Tissue with Microsystems," in Neural Engineering, B. He, Ed. Chicago: Kluwer Academics, 3:488, ISBN 0-306-48609-1, 2005
  2. P. A. Passeraub, “An Integrated Inductive Proximity Sensor”, Series in Microsystems, vol. 1, Besse, P. A., Gijs M., Popovic R. S., Renaud Ph. , Ed. Konstanz. Hartung-Gorre Verlag, ISBN 3-89649-430-9, 1999

Journal Articles

  1. Prim, D., F. Rebeaud, V. Cosandey, R. Marti, P. Passeraub, and M. Pfeifer, ADIBO-Based “Click” Chemistry for Diagnostic Peptide Micro-Array Fabrication: Physicochemical and Assay Characteristics. Molecules, 2013. 18(8): p. 9833-9849.
  2. Vincent Cosandey, Fabien Debrot, Jérémy Kaeser, Roger Marti, Philippe Passeraub, Jannick Pétremand, Denis Prim, and Marc E. Pfeifer, “Construction of a Peptide Microarray for Auto-antibody Detection”, CHIMIA 2012, 66, No. 10, pp. 802-805, 2012.
  3. M. Jobin, P. Passeraub and R. Foschia, "Nanometrology for MEMS: combination of optical interference, atomic force microscopy, and nanoindentor-based actuator," Proceedings of SPIE, Optical Micro- and Nanometrology in Microsystems Technology, vol. 6188, 2006.
  4.  P. A. Passeraub, A. C. Almeida, and N. V. Thakor, "Design, microfabrication and characterization of a microfluidic chamber for the perfusion of brain tissue slices," Biomedical Microdevices, vol. 5, pp. 147-155, 2003.
  5.  P. A. Passeraub, P.-A. Besse, and R. S. Popovic, “Temperature compensation of an integrated low power inductive proximity microsensor,” Sensors and Actuators A, vol. 82, pp. 62-68, 2000
  6.  P. A. Passeraub, P.-A. Besse, A. Bayadroun, E. Bernasconi, and R. S. Popovic, “First integrated inductive proximity sensor with on-chip CMOS readout circuit and electrodeposited 1 mm flat coil,” Sensors and Actuators A, vol. 76, pp. 273-278, 1999
  7.  P. A. Passeraub, P.-A. Besse, S. Hediger, C. d. Raad, and R. S. Popovic, “High resolution miniaturized inductive proximity sensor: characterization and application for step motor control,” Sensors and Actuators A, vol. 68, pp. 257-262, 1998
  8.  P. A. Passeraub, P.-A. Besse, C. d. Raad, O. Dezuari, F. Quinet, and R. S. Popovic, “Metallic profile and coin imaging using an inductive proximity sensor microsystem,” Sensors and Actuators A, vol. 66, pp. 225-230,
  9.  P. A. Passeraub, G. Rey-Mermet, P.-A. Besse, H. Lorenz, and R. S. Popovic, “Inductive proximity sensor with a flat coil and a new differential relaxation oscillator,” Sensors and Actuators A, vol. 60, pp. 122-126, 1997
  10.  P. A. Passeraub, P.-A. Besse, C. d. Raad, and R. S. Popovic, “A differential relaxation oscillator as a versatile electronic interface for sensors,” Sensors and Actuators A, vol. 58, pp. 141-148, 1997
  11.  P. A. Passeraub, P.-A. Besse, and R. S. Popovic, “Scaling down an inductive proximity sensor,” Sensors and Actuators A, vol. 52, pp. 114-118, 1996

Conference papers, presentations and other publications

  1. Schoinas, S., A.-M.E. Guamra, F. Moreillon, and P. Passeraub, A flexible pad-printed fluxgate sensor, in Eurosensors 2017. sumitted: Paris.
  2. Guamra, A.E., E. Condemi, M. Pfeifer and P. Passeraub, Evaluation of a pad printed affinity biosensor suitable for large-scale production, to be presented at the 5th International Conference on Bio-Sensing Technology, 7-10 May, 2017. Riva del Garda, Italy
  3. Passeraub, P., D. Bionda, and C. Rouiller, JMM - Journée des Microtechniques Médicales 2016, in Evénement de la Conférence des Chefs de Département de l'Economie publique de Suisse Occidentale. 2016: Fribourg, Suisse.
  4. Passeraub, P., F. Moreillon, and A.E. Guamra, Fabrication de circuits imprimés par impression d’encres : une alternative plus durable ?, in CONFREGE 2016. 2016: Genève, Suisse.
  5. Guamra, A.E., E. Condemi, F. Moreillon, M. Pfeifer, J. Moerschell, M. Mazza, M. Dellea, and P. Passeraub, Progrès vers la détection de biomarqueurs non-optique, in Journées de Microtechniques Médicales 2015. 2015: Genève, Suisse.
  6. Passeraub, P., B. Schnyder, A.E. Guamra, F. Moreillon, Z. Andrieu, D.D. Giudice, T. Duchesne, G. Fischler, A. Roux, A. Sandoz, M. Mazza, M. Dellea, J.-L. Bolli, and L. Stoppini, Progrès vers le monitorage de longue durée la structure et de la fonction de barrières tissulaires et cellulaires, in Journées de Microtechniques Médicales 2015, 2015 : Genève, Suisse.
  7. A.-M.E. Guamra, D. Bühlmann, F. Moreillon, L. Vansteenkiste, P. Büchler, A. Stahel, and P. Passeraub, Simulation and Experimental Characterizations of a Thin Touch Mode Capacitive Pressure Sensor, in COMSOL Conference 2015. 2015: Grenoble, France.
  8. Astl, G., J. Essinger, P. Passeraub, R. Yazigi, and T. Weber, Peut-on innover dans le cadre d’une PME Medtech ?, in Table ronde dans le cadre du congrès EPHJ - EPMT - SMT. 2015: Genève, Suisse.
  9. Passeraub, P., F. Moreillon, and Z. Andrieu, Ciliametrix: un instrument de mesure pour le monitorage in vitro d'activité dynamique de cultures tissulaires, in TechLunch du GCC. 2014: Genève, Suisse.
  10. Passeraub, P., F. Moreillon, D. Bühlmann, A.E. Guamra, R. Beuchat, and D. Bechevet, Avancées vers la fabrication de circuits flexibles double couche par tampographie, in MECATRONIC / PLASTRONIC Connection 2014. 2014: Grenoble, France.
  11. Ph. Passeraub, DiagnoTox Plateforme pour le diagnostic in vitro de toxicité à faibles doses, in Carrefour des créateurs (Genilem). 2014: SWISSTECH CONVENTION CENTER (EPFL), Suisse.
  12. Passeraub, P., Evaluation de projets dans H2020 : processus, critères et conseils, in H2020 Health Info Event. 2014: Lausanne, Suisse
  13. Pasquale, P.D., A. Sandoz, I. Charvet, P. Passeraub, M. Chiappalone, and L. Stoppini, Development of a Stand-alone Integrated MEA Biochip System for Chronic Recordings, in MEA Meeting 2014. 2014: Tübingen, Germany.
  14. Passeraub, P. and L. Stoppini, Contributions at HES-SO on Smart Systems for Healthcare, in Inartis Network Workshop on Smart Systems for Life Sciences. 2014: Technopark Zurich, Switzerland.
  15. Passeraub, P., F. Moreillon, D. Bühlmann, and A.E. Guamra, La tampographie: une méthode simple de fabrication de biocapteurs, in Journée des Microtechniques Médicales. 2014: Genève, Suisse.
  16. Passeraub, P., F. Moreillon, D. Bühlmann, and A.E. Guamra, La tampographie: une méthode prometteuse d'Impression de microsystèmes capteurs, in TechLunch du GCC. 2014: Genève, Suisse.
  17. Passeraub, P., F. Moreillon, A.E. Guamra, D. Bühlmann, and L. Stoppini, Dépose de couches fonctionnelles pour dispositifs médicaux à usage unique : la tampographie comme méthode prometteuse de fabrication à faible coût, in MEDTEC France. 2014: Lyon (France).
  18. Stoppini, L. and P. Passeraub, Development of Multi-Electrode Arrays (M.E.A) for chronic monitoring of 3D neural tissues derived from human Stem Cells, in Workshop 2D Printing Digitale Druckverfahren zur Herstellung funktionaler Schichten. 2013: Fribourg, Suisse.
  19. Passeraub, P., La spectroscopie par impédance de tissus biologique : une vieille technologie en pleine cure de jouvence, in Journées de Microtechniques Médicales. 2013: Palexpo, Genève, Suisse.
  20. Stoppini, L., P. Passeraub, F. Lefort, and Y. Leuzinger, Hepia, an academic powerhouse for biotech transfers, in BILAN. 2012.
  21. Vincent Cosandey, Fabien Debrot, Jérémy Kaeser, Roger Marti, Philippe Passeraub, Jannick Pétremand, Denis Prim, and Marc E. Pfeifer, “Peptide Microarrays by Click Chemistry for Applications in Cancer Diagnostics”, Swiss Chemical Society – 2012 Fall Meeting, Zurich, Switzerland, 2012.
  22.  M. Heuschkel, T. Kauffmann, L. Sundstrom, J.-F. Beche, S. Gharbi, S. Bonnet, R. Guillemaud, P. Passeraub, D. Hakkoum, L. Stoppini, K. Georgy, J.-R. Péclard, H. Satizabal Mejia, A. Perez-Uribe, and M. Kopanitsa, The PharMEA Platform: A High Throughput Data Acquisition Instrument Integrating Real-Time Data Analysis, Data Reduction, and Wellplate-Format Microelectrode Arrays”, the 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012, Reutlingen, Germany, July 10 - 13, 2012.
  23.  L. Stoppini; D. Hakkoum; A. Sandoz;  P. Passeraub; Fabien Moreillon; W. Andlauer; B  Schnyder ; KH Krause ; M. Jaconi; H. Keppner; S. Brun; J. Brossard, Stem-3D “Multi-Organs-on-a-Chip”: tools for “Human-based in vitro testing systems”, the 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012, Reutlingen, Germany, July 10 - 13, 2012.
  24.  L. Stoppini, A. Sandoz, D. Hakkoum, I. Charvet, S. Julien, O. Preynat-Seauve, M. Dubois-Dauphin, P. Passeraub , F. Moreillon, KH Krause, “3D engineered nervous tissues derived from mouse and human embryonic stem cells as in vitro models for neurotoxicity studies”, Meeting Patch-Clamp, Montpellier, France, June 2012.
  25.  P. A. Passeraub, F. Moreillon, D. Morenzoni, J. Meyer, J. Perret, D. Hakkoum, and L. Stoppini, "Diagnotox: une plateforme innovante d'instruments pour le diagnostic in vitro de toxicité à faibles doses et sur le long terme," in Brochure HES, A. B. M. Cassard, M.Torbay, Ed. Genève: HES-SO Genève, 2011, pp. 7.
  26. P. Passeraub and L. Stoppini, "Dispositifs microfluidiques pour tests de toxicité in vitro," in MECATRONIC Connection 2011. Yverdon-les-Bains, Suisse: Thésame, 2011.
  27. P. Passeraub, F. Moreillon, D. Hakkoum, L. Stoppini, and M. O. Heuschkel, "Pad printing microelectrode arrays onto a porous polymer membrane: a promising low cost fabrication process," in Swiss ePrint. Basel, Switzerland: FSRM, 2011.
  28. I. Annessi-Ramseyer, N. Turck, P. Passeraub, L. Borradori, B. Favre, D. F. Hochstrasser, L. Fontao, and C. G. Zimmermann-Ivol, "MULTIPLE AUTOANTIBODIES DETECTION FOR BULLOUS PEMPHIGOID DIAGNOSIS BY PROTEIN MICROARRAY," in SSDV 2011. Geneva, 2011.
  29. I. Annessi-Ramseyer, P. Passeraub, N. Turck, L. Borradori, B. Favre, D. F. Hochstrasser, L. Fontao, and C. G. Zimmermann-Ivol, "MULTIPLE AUTOANTIBODIES DETECTION FOR BULLOUS PEMPHIGOID DIAGNOSIS BY PROTEIN MICROARRAY," in HUPO 2011. Geneva, 2011.
  30. P. A. Passeraub, L. Stoppini, F. Lefort, H. Keppner, H. Haquette, K. Eyer, L. Wiszniewski, and S. Constant, "Development and application of a multifunctional platform for the long term in vitro toxicity screening and efficacy testing," in BioInnovation Day 2010. CHUV, Lausanne, Switzerland, 2010.
  31. P. A. Passeraub, L. Stoppini, H. Keppner, H. Haquette, K. Eyer, U. Frey, L. Wiszniewski, and S. Constant, "Plateforme multifonctionnelle pour le diagnostic de la toxicité in vitro à long terme," in Journée de valorisation des CALL 2007. Lausanne, Switzerland, 2010.
  32. P. A. Passeraub, L. Stoppini, H. Keppner, H. Haquette, K. Eyer, U. Frey, L. Wiszniewski, and S. Constant, "A multifunctional platform for the real-time in vitro diagnostic of long term toxicity," in IVTIP Spring Meeting 2010 (In Vitro Testing Industrial Platform). Geneva, Switzerland, 2010.
  33. P. A. Passeraub, "Miniaturisation, systèmes mécatroniques et innovation technologique en bio-ingénierie," in 92?me Journée technique. Cité des Entreprises, Lyon: Ardi-Rhônes-Alpes Santé, 2009.
  34. P. A. Passeraub, "Chaîne de mesure de type EEG compatible avec les bio-signaux extrêmement lents," in alliance info, 2007, pp. 3-4.
  35. O. Roux, L. Stoppini, and P. A. Passeraub, "Optimizing gold microelectrodes for slow biopotential measurement using an electrodeposited Polypyrrole/DBSA layer," presented at Swiss Society of Biomedical Engineering 2007 Meeting, CSEM, Neuchâtel, Switzerland, 2007.
  36. F. Moreillon, R. d. Agosti, and P. A. Passeraub, "Development of a low-noise 64-channel measurement system for low frequency bioelectrical signals," presented at Swiss Society of Biomedical Engineering 2007 Meeting, CSEM, Neuchâtel, Switzerland, 2007.
  37.  P. A. Passeraub, "New postgraduate bio-engineering course in Geneva," presented at BMT 2006, Gemeinsame Jahrestagung des Schweizerischen, Deutschen un Österreichischen Gesellschaft für Biomedizinische Technik, Zürich, 2006.
  38. K. T Haraldsson and P. A. Passeraub, "Fabrication of a geometrically complex brain slice perfusion device via contact liquid photolithographic polymerization (CLiPP)", presented at the International Conference on Multi-Material Micro Manufacture (4M), Karlsruhe, Germany, 2005.
  39. P. A. Passeraub, M. C. Emerick, T. Haraldsson, A. C. Almeida, and N. V. Thakor, "A system for multiple, independent manipulation of local bath composition at sites distributed over the surface of a brain slice," presented at Neuroscience, New Orleans, Louisiana (USA), 2003.
  40. M. Naware, N. V. Thakor, R. N.Orth, K. Murari, and P. A. Passeraub, "Design and Microfabrication of a Polymer-Modified Carbon Sensor Array for the Measurement of Neurotransmitter Signals," presented at 25th annual international conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 2003.
  41. P. A. Passeraub, A. C. Almeida, and N. V. Thakor, "Design and Microfabrication of an Interface Chamber with Integrated Arrays of Microelectrodes for Brain Slice Studies," presented at BioMEMs & Biomedical Nanotech WORLD 2003, Washington DC, USA, 2003.
  42. M. Naware, P. A. Passeraub, R. N. Orth, K. Murari, M. Paranjape, and N. V. Thakor, "Microfabrication and Characterization of a Polymer Modified Biological NO Sensor Array," presented at BioMEMs & Biomedical Nanotech WORLD 2003, Washington DC, USA, 2003.
  43. P. A. Passeraub, D. L. Sherman, M. Naware, A. Rege, and N. V. Thakor, "Microdialysis Probing for Brain Research: Microfluidic and Biosensing Challenges," presented at Microfluidics/Biosensor Workshop at the University of Pennsylvania, Philadelphia, PA, USA, 2003.
  44. P. A. Passeraub, A. C. Almeida, and N. V. Thakor, "A microfabricated fluidic chamber for the perfusion of brain slices," presented at 2nd Joint Conference of the Engineering in Medicine and Biology Society of the IEEE and the Biomedical Engineering Society, Houston, Texas USA, 2002.
  45. P. A. Passeraub, A. C. Almeida, and N. V. Thakor, "Optimal perfusion of brain slices using a new microfluidic chamber," presented at BioMEMs & Biomedical Nanotech WORLD 2002, Columbus, Ohio USA, 2002.
  46. M. Naware, P. A. Passeraub, G. Mulliken, R. N. Orth, J. Currie, M. Paranjape, and N. V.Thakor, "Microfabrication advances for the spatio-temporal characterization of neurochemical concentrations," presented at BioMEMs & Biomedical Nanotech WORLD 2002, Columbus, Ohio USA, 2002.
  47. G. Mulliken, A. C. Almeida, P. A. Passeraub, N. Thakor, “Spatio-Temporal Characterization of Spreading Depression in Retina: Effects of Focal Drug Perfusion”, presented at the Biomedical Engineering Society's Conference in Durham, NC, USA, Oct. 4-7, 2001.
  48.   P. A. Passeraub, K. Dass, M. Jufer, “Innovation management and Outsourcing”, presented at the 1999 ABB-EPFL day, Swiss Federal Institute of Technology – Lausanne, Oct. 6, 1999.
  49. P. A. Passeraub, P.-A. Besse, and R. Popovic, “Temperature compensation of an integrated low power inductive proximity microsensor,” presented at Transducers 99, the 10th International Conference on Solid-State Sensors and Actuators, Sendai (Japan), 1999.
  50. R. Vuillemin, B. Aeschlimann, M. Kuermmerle, J. Zoethout, T. Belfroid, H. Bleuler, A. Cassat, P. A. Passeraub, S. Hediger, P.-A. Besse, A. Argondizza, A. Tonoli, S. Carabelli, G. Genta, and G. Heine, “Low Cost Active Magnetic Bearings for Hard Disk Drive Spindle Motors,” presented at The Sixth International Symposium on Magnetics Bearings, Cambridge, MA (USA), 1998.
  51. P. A. Passeraub, P.-A. Besse, A. Bayadroun, E. Bernasconi, and R. S. Popovic, “First integrated inductive proximity sensor with on-chip CMOS readout circuit and electrodeposited 1 mm flat coil,” in Eurosensors XII, Proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, vol. 1, Sensors Series, Eurosensors XII, N. M. White, Ed. Southampton, United Kingdom: Institute of Physics Publishing, 1998, pp. 575-578.
  52. P. A. Passeraub, P.-A. Besse, C. d. Raad, and R. S. Popovic, “High Resolution Miniaturized Inductive Proximity Sensor,” presented at The 11th European Conference on solid-state transducers, Warsaw, Poland, 1997.
  53. P. A. Passeraub, P.-A. Besse, C. d. Raad, O. Dezuari, F. Quinet, and R. S. Popovic, “Coin Recognition Using an Inductive Proximity Sensor Microsystem,” presented at Transducers'97, Chicago, USA, 1997.
  54. P. A. Passeraub, G. Rey-Mermet, P.-A. Besse, H. Lorenz, and R. S. Popovic, “Inductive Proximity Sensor with a Flat Coil and a New Differential Relaxation Oscillator,” presented at The 10th European Conference on solid-state transducers, Leuven, Belgium, 1996.
  55. P. A. Passeraub, P.-A. Besse, and R. S. Popovic, “Scaling down an inductive proximity sensor,” presented at Transducers'95, Stockholm, Sweden, 1995.

Short movie

  1. P. A. Passeraub, “Un capteur de proximité inductif intégré”, movie on research illustration, selected and awarded Film at the 5th research movie festival, Nancy, France, March 27th – April 1st, 2000.